Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness.

ABSTRACT: Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can improve existing diagnostic and treatment strategies. Extracellular matrix (ECM) remodeling and cancer-associated fibroblasts play a crucial role in the regulation of cancer aggressiveness and there is a growing need to investigate their role in the determination of LUAD behavior at early stages. We analyzed tissue samples isolated from patients with LUAD at early stages and used imaging-based biomarkers to predict LUAD behavior. Single-cell RNA sequencing and histological assessment showed that aggressive LUADs are characterized by a decreased number of

SUBMITTER: Vasiukov G 

PROVIDER: S-EPMC10582049 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature