Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy.

ABSTRACT: Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments. Here, we utilized single-cell transcriptomic analysis and integrated clinical observations and laboratory examination to dissect the host immune responses and reveal pathological mechanisms in COVID-19-associated pediatric encephalopathy. We found that lymphopenia was a prominent characteristic of immune perturbation in COVID-19 patients with encephalopathy, especially those with acute necrotizing encephalopathy (AE). This was characterized a marked reduction of various lymphocytes (e.g., CD8⁺ T and CD4⁺ T cells) and significant increases in other inflammatory cells (e.g., monocytes). Further analysis revealed activation of

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10582072 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature