Maternal immune activation during pregnancy is associated with more difficulties in socio-adaptive behaviors in autism spectrum disorder.

ABSTRACT: Autism spectrum disorder (ASD) are neurodevelopmental conditions characterised by deficits in social communication and interaction and repetitive behaviours. Maternal immune activation (MIA) during the mid-pregnancy is a known risk factor for ASD. Although reported in 15% of affected individuals, little is known about the specificity of their clinical profiles. Adaptive skills represent a holistic approach to a person's competencies and reflect specifically in ASD, their strengths and difficulties. In this study, we hypothesised that ASD individual with a history of MIA (MIA⁺) could be more severely socio-adaptively impaired than those without MIA during pregnancy (MIA^-). To answer this question, we considered two independent cohorts of individuals with ASD (PARIS stu

SUBMITTER: Ellul P 

PROVIDER: S-EPMC10582088 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature