Quantitative [⁶⁸Ga]Ga-PSMA-11 PET biomarkers for the analysis of lesion-level progression in biochemically recurrent prostate cancer: a multicentre study.

ABSTRACT: [⁶⁸Ga]Ga-PSMA-11 PET has become the standard imaging modality for biochemically recurrent (BCR) prostate cancer (PCa). However, its prognostic value in assessing response at this stage remains uncertain. The study aimed to assess the prognostic significance of radiographic patient-level patterns of progression derived from lesion-level biomarker quantitation in metastatic disease sites. A total of 138 BCR PCa patients with both baseline and follow-up [⁶⁸Ga]Ga-PSMA-11 PET scans were included in this analysis. Tumour response was quantified at the lesion level using commonly used quantitative parameters (SUV_mean, SUV_max, SUV_peak, volume), and patients were classified as systemic, mixed, or no-progression based on these response classific

SUBMITTER: Kendrick J 

PROVIDER: S-EPMC10582101 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature