Pheromone of grouped female mice impairs genome stability in male mice through stress-mediated pathways.

ABSTRACT: Population density is known to affect the health and survival of many species, and is especially important for social animals. In mice, living in crowded conditions results in the disruption of social interactions, chronic stress, and immune and reproductive suppression; however, the underlying mechanisms remain unclear. Here, we investigated the role of chemosignals in the regulation of mouse physiology and behavior in response to social crowding. The pheromone 2,5-dimethylpyrazine (2,5-DMP), which is released by female mice in crowded conditions, induced aversion, glucocorticoid elevation and, when chronic, resulted in reproductive and immune suppression. 2,5-DMP olfaction induced genome destabilization in bone marrow cells in a stress-dependent manner, providing a plausible mechanism fo

SUBMITTER: Glinin TS 

PROVIDER: S-EPMC10582102 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature