Tomato lipidic extract plus selenium decrease prostatic hyperplasia, dihydrotestosterone and androgen receptor expression versus finasteride in rats.

ABSTRACT:

Purpose

Evaluate the therapeutic effect of a tomato lipidic extract (STE) in combination with selenium (Se) on rats with prostatic hyperplasia (PH) and to observe its possible mechanisms of action and synergism versus finasteride.

Materials and methods

54 male Wistar rats of nine weeks old were divided in Control (C), PH, Finasteride (F), STE, Se, F + STE, F + Se, STE + Se and F + STE + Se with testosterone enanthate (except C). After 4 weeks of treatment administration, prostate weight, bladder weight, diuresis, prooxidant and antioxidant activity, dihydrotestosterone (DHT), androgen receptor (AR) expression and anatomopathological analysis were determined.

Results

STE + Se decreased prostate weight 53.8% versus 28% in F group, also STE + Se decreased significatively

SUBMITTER: Arias-Chavez DJ 

PROVIDER: S-EPMC10582118 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature