Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarized ¹²⁹Xe.

ABSTRACT:

Background

Absolute temperature measurements of tissues inside the human body are difficult to perform non-invasively. Yet, for brown adipose tissue (BAT), these measurements would enable direct monitoring of its thermogenic activity and its association with metabolic health.

Methods

Here, we report direct measurement of absolute BAT temperature in humans during cold exposure by magnetic resonance (MR) with laser polarized xenon gas. This methodology, which leverages on the sensitivity of the chemical shift of the ¹²⁹Xe isotope to temperature-induced changes in fat density, is first calibrated in vitro and then tested in vivo in rodents. Finally, it is used in humans along with positron emission tomography (PET) scans with fluorine-18-fluorodeoxyglucose to detect

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10582175 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature