Electrode montage for transcranial direct current stimulation governs its effect on symptoms and functionality in schizophrenia.

ABSTRACT:

Backgrounds

Patients with schizophrenia suffer from cognitive impairment that worsens real-world functional outcomes. We previously reported that multi-session transcranial direct current stimulation (tDCS) delivered to the left dorsolateral prefrontal cortex (DLPFC) improved daily living skills, while stimulation on the left superior temporal sulcus (STS) enhanced performance on a test of social cognition in these patients. To examine the region-dependent influence of tDCS on daily-living skills, neurocognition, and psychotic symptoms, this study compared effects of anodal stimulation targeting either of these two brain areas in patients with schizophrenia.

Methods

Data were collected from open-label, single-arm trials with anodal electrodes placed over the left DLPFC (N = 

SUBMITTER: Yamada Y 

PROVIDER: S-EPMC10582326 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature