A potential role of mechano-gated potassium channels in meningioma-related seizures.

ABSTRACT: Every third patient with intracranial meningioma develops seizures of poorly understood etiology. Tumor and peritumoral edema may exert mechanical pressure on the cortex that may affect mechano-gated potassium channels - KCNK2 and KCNK4. These channels regulate neuron excitability and have been related to seizures in some other conditions. The objective of the present study was to explore a potential relation between the levels of these proteins in tumor tissue and adjacent cortex and seizures development. The study included 19 meningioma patients that presented one or more preoperative seizures and 24 patients with no seizures. Tissue samples were collected in the course of surgical removal of the meningioma. Postoperative seizure freedom was achieved in 11 out of 19 patients. The relativ

SUBMITTER: Bogdanovic I 

PROVIDER: S-EPMC10582377 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature