New hybrid radio-fluorescent probes [¹³¹I]-BPF-01 and [¹³¹I]-BPF-02 for visualisation of cancer cells: Synthesis and preliminary in vitro and ex vivo evaluations.

ABSTRACT: We synthesised and biologically evaluated two new hybrid probes [¹³¹I]BPF-01 and [¹³¹I]BPF-02 which were built from three structural entities: benzothiazole-phenyl, fluorescein isothiocyanate (FITC), and iodine-131. These probes were designed for potential applications in assisting surgical procedures of solid cancers. The cytotoxicity study demonstrated that fluorescent probes BPF-01 (31.23 μg/mL) and BPF-02 (250 μg/mL) were relatively not toxic to normal immortalized human keratinocytes (HaCaT) cells, as indicated by the percentage of cell survival above 50 %. Furthermore, both probes displayed low to moderate anticancer activity against the breast cancer cells (MDA-MB-231) and prostate cancer cells (LNCaP and

SUBMITTER: Wongso H 

PROVIDER: S-EPMC10582398 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature