Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks.

ABSTRACT: Astrocytes are diverse brain cells that form large networks communicating via gap junctions and chemical transmitters. Despite recent advances, the functions of astrocytic networks in information processing in the brain are not fully understood. In culture, brain slices, and in vivo, astrocytes, and neurons grow in tight association, making it challenging to establish whether signals that spread within astrocytic networks communicate with neuronal groups at distant sites, or whether astrocytes solely respond to their local environments. A multi-electrode array (MEA)-based device called AstroMEA is designed to separate neuronal and astrocytic networks, thus allowing to study the transfer of chemical and/or electrical signals transmitted via astrocytic networks capable of changing neuronal e

SUBMITTER: Hastings N 

PROVIDER: S-EPMC10582426 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature