Controlled Release of Hydrogen-Carrying Perfluorocarbons for Ischemia Myocardium-Targeting ¹⁹ F MRI-Guided Reperfusion Injury Therapy.

ABSTRACT: Hydrogen gas is recently proven to have anti-oxidative and anti-inflammation effects on ischemia-reperfusion injury. However, the efficacy of hydrogen therapy is limited by the efficiency of hydrogen storage, targeted delivery, and controlled release. In this study, H₂ -PFOB nanoemulsions (NEs) is developed with high hydrogen loading capacity for targeted ischemic myocardium precision therapy. The hydrogen-carrying capacity of H₂ -PFOB NEs is determined by gas chromatography and microelectrode methods. Positive uptake of H₂ -PFOB NEs in ischemia-reperfusion myocardium and the influence of hydrogen on ¹⁹ F-MR signal are quantitatively visualized using a 9.4T MR imaging system. The biological therapeutic effects of H₂ -PFOB NEs are exami

SUBMITTER: Nie C 

PROVIDER: S-EPMC10582447 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature