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The second near-infrared fluorescence concealed imaging for identifying smuggled baggage.

ABSTRACT: Smuggling methods are renovating with more diversified, complicated means, thereby developing concealed and non-sensitive luggage identification technology is of great significance. Herein, for the first time, the second near-infrared (NIR-II, 1000-2500 nm) concealed imaging for identifying smuggled baggage based on organic small molecule luminescent material was studied. A small molecule luminescent material (Y6) with the excitation in invisible near-infrared (NIR) light was used to generate fluorescence-emission in NIR-II region. The traceless Y6 sprayed on the surface of criminal luggage does not emit light under visible light irradiation, but shows hidden NIR-II signs under NIR excitation that can prevent the suspects to find abnormality and lose their luggage. The Y6 organic luminescent material has invisibility, low toxicity, long-term fluorescence stability and high transparency. This NIR-II fluorescence imaging technology can be used as a new type of concealed baggage marking, which is of great significance to help the customs combat smuggling crimes.

SUBMITTER: Cai Y

PROVIDER: S-EPMC10582487 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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The second near-infrared fluorescence concealed imaging for identifying smuggled baggage.

Cai Yu Y Wang Jinling J Ou Changjin C Zhu Yuanyuan Y Fang Jing J Hong Ying Y

Heliyon 20231011 10

Smuggling methods are renovating with more diversified, complicated means, thereby developing concealed and non-sensitive luggage identification technology is of great significance. Herein, for the first time, the second near-infrared (NIR-II, 1000-2500 nm) concealed imaging for identifying smuggled baggage based on organic small molecule luminescent material was studied. A small molecule luminescent material (Y6) with the excitation in invisible near-infrared (NIR) light was used to generate fl ...[more]

PMID: 37860536

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Project description:PurposeNear-infrared fluorescence (NIRF) imaging has been widely used in preclinical studies; however, its low tissue penetration represents a daunting problem for translational clinical imaging of neurodegenerative diseases. The retina is known as an extension of the central nerve system (CNS), and it is widely considered as a window to the brain. Therefore, the retina can be considered as an alternative organ for investigating neurodegenerative diseases, and an eye represents an ideal NIRF imaging organ, due to its minimal opacity.ProceduresNIRF ocular imaging (NIRFOI), for the first time, was explored for imaging of Alzheimer's disease (AD) via utilizing "smart" fluorescent probes CRANAD-X (X = - 2, - 3, - 30, - 58, and - 102) for amyloid beta (Aβ), and CRANAD-61 for reactive oxygen species (ROS). Mice were intravenously injected the fluorescence dyes and images from the eyes were captured with an IVIS imaging system at different time points.ResultsAll of the tested NIRF probes could be used to differentiate transgenic AD mice and WT mice, and NIRFOI could provide much higher sensitivity for imaging Aβs than NIRF brain imaging did. Our data suggested that NIRFOI could capture the imaging signals from both soluble and insoluble Aβ species. Moreover, we demonstrated that NIRFOI with CRANAD-102 could be used to monitor the therapeutic effects of BACE-1 inhibitor LY2811376. Compared to NIRF brain imaging, NIRFOI provided a larger change of Aβ levels before and after LY2811376 treatment. In addition, we demonstrated that CRANAD-61 could be used to image reactive oxygen species in the eyes.ConclusionThe large detection margin by NIRFOI is very important for both diagnosis and therapy response monitoring. Compared to fluorescence microscopic imaging, NIRFOI captures signals with a wide angle (large field of view (FOV)) and can be used to detect soluble Aβs. We believe that NIRFOI has remarkable translational potential for future human studies and can be a potential imaging technology for fast, cheap, accessible, and reliable screening of AD in the future.

Dataset Information

The second near-infrared fluorescence concealed imaging for identifying smuggled baggage.

Publications

The second near-infrared fluorescence concealed imaging for identifying smuggled baggage.

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