A novel prognostic signature and potential therapeutic drugs based on tumor immune microenvironment characterization in breast cancer.

ABSTRACT: Tumor microenvironment (TME) is closely correlated to the occurrence and progression of breast cancer, however its potentiality in assisting diagnosis and therapeutic decision remains unclear. Therefore, the major aim of this study is to explore the prognostic value of TME related gene in breast cancer. Expression matrices and clinical data of breast cancer obtained from public databases were divided into TME relevant clusters according to immune characterization. A 12-gene molecular classifier was generated through the utilization of differentially expressed genes identified between distinct Tumor Microenvironment (TME) clusters, coupled with correlative regression analysis. The performance of this TME-driven prognostic signature (TPS) were examined across both the training and validation

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10582509 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature