Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer.

ABSTRACT:

Purpose

Loss-of-function mutations in the adenomatous polyposis coli (APC) gene are common in metastatic colorectal cancer (mCRC). However, the characteristic of APC specific mutations in mCRC is poorly understood. Here, we explored the clinical and molecular characteristics of N-terminal and C-terminal side APC mutations in Chinese patients with mCRC.

Materials and methods

Hybrid capture-based next-generation sequencing was performed on tumor tissues from 275 mCRC pati-ents to detect mutations in 639 tumor-associated genes. The prognostic value and gene-pathway difference between APC specific mutations in mCRC patients were analyzed.

Results

APC mutations were highly clustered, accounting for 73% of all mCRC patients, and most of them were truncating mutations. The t

SUBMITTER: Peng H 

PROVIDER: S-EPMC10582542 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature