Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.

ABSTRACT: Loss of consciousness is a hallmark of many epileptic seizures and carries risks of serious injury and sudden death. While cortical sleep-like activities accompany loss of consciousness during focal impaired awareness seizures, the mechanisms of loss of consciousness during focal to bilateral tonic-clonic seizures remain unclear. Quantifying differences in markers of cortical activation and ictal recruitment between focal impaired awareness and focal to bilateral tonic-clonic seizures may also help us to understand their different consequences for clinical outcomes and to optimize neuromodulation therapies. We quantified clinical signs of loss of consciousness and intracranial EEG activity during 129 focal impaired awareness and 50 focal to bilateral tonic-clonic from 41 patients. We chara

SUBMITTER: Juan E 

PROVIDER: S-EPMC10582624 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature