TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma.
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ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC10582671 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma.
Yu Hao H Zhu Kai K Wang Minjie M Jiang Xiaobing X
Clinical and translational science 20230810 10
Ferroptosis is an iron-dependent cell death process mainly triggered by reactive oxygen species (ROS) and lipid peroxidation. Thioredoxin domain protein 12 (TXNDC12) promotes the development of some tumors; however, its function in tumor ferroptosis remains unclear. In this study, we found that knockdown of TXNDC12 promoted erastin-induced increase in ROS, lipid peroxidation, and Fe<sup>2+</sup> levels, and decreased glutathione content. TXNDC12 is involved in ferroptosis by regulating SLC7A11. ...[more]
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