Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia.

ABSTRACT: Glutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L-glutamate is a neurotransmitter that acts on glutamate receptors. However, the role of glutamate receptors in AML is largely understudied. Here, we comprehensively analyze the genomic and transcriptomic alterations of glutamate receptor genes in AML using publicly available data. We investigated the frequency of mutations in the glutamate receptor genes and whether an association exist between the presence of these mutations and clinical and molecular characteristics or patient's clinical outcome. We also assessed the dysregulation of glutamate receptor gene expression in AML with and without mutations and

SUBMITTER: Alqahtani A 

PROVIDER: S-EPMC10582680 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature