Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications.

ABSTRACT: Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing

SUBMITTER: Li N 

PROVIDER: S-EPMC10582706 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature