Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults.

ABSTRACT:

Objective

To determine the extent to which the regional brain volumes associated with slow gait speed can inform subsequent cognitive decline in older adults from the Rush Memory and Aging Project.

Approach

We utilized deformation-based morphometry (DBM) in a whole-brain exploratory approach to identify the regional brain volumes associated with gait speed assessed over a short distance during an in-home assessment. We created deformation scores to summarize the gait-associated regions and entered the scores into a series of longitudinal mixed effects models to determine the extent to which deformation predicted change in cognition over time, controlling for associations between gait and cognition.

Results

In 438 older adults (81 ± 7; 76% female), DBM revealed that sl

SUBMITTER: Poole VN 

PROVIDER: S-EPMC10582745 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature