The association between lifelong personality and clinical phenotype in the FTD-ALS spectrum.

ABSTRACT:

Introduction

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two phenotypes of the same neurodegenerative disease, the FTD-ALS spectrum. What determines the development of one rather than the other phenotype is still unknown. Based on the clinical observation that patients' personality seems to differ between the two phenotypes, i.e., ALS patients tend to display kind, prosocial behaviors whereas FTD patients tend to present anti-social behaviors, and that these traits are often reported as pre-existing the disease onset by caregivers, we set up to study experimentally patients' personality in their premorbid life.

Methods

We first tested for differences between groups, then tested the association between premorbid personality and current functional

SUBMITTER: Vinceti G 

PROVIDER: S-EPMC10582748 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature