Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis.

ABSTRACT:

Background & aims

HBV infection is one of the leading causes of liver cirrhosis. However, the immune microenvironment in patients with HBV cirrhosis remains elusive.

Methods

Single-cell RNA sequencing was used to analyse the transcriptomes of 76,210 immune cells in the livers of six healthy individuals and in five patients with HBV cirrhosis.

Results

Patients with HBV cirrhosis have a unique immune ecosystem characterised by an accumulation of macrophage-CD9/IL18, macrophage-C1QA, NK Cell-JUNB, CD4⁺ T cell-IL7R, and a loss of B cell-IGLC1 clusters. Furthermore, our analysis predicted enhanced cell communication between myeloid cells and all immune cells in patients with HBV-related cirrhosis. Pseudo-time analysis of myeloid cells, natural killer (NK) cells,

SUBMITTER: Bai Q 

PROVIDER: S-EPMC10582775 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature