Implications of isolated white matter abnormalities on neonatal MRI in congenital CMV infection: a prospective single-centre study.

ABSTRACT:

Objective

Investigating the clinical implications of isolated white matter abnormalities on neonatal brain MRI in congenital cytomegalovirus (CMV).

Design

Prospective, observational.

Patients/interventions

Two paediatric radiologists, blinded to clinical data, independently scored the white matter in 286 newborns with congenital CMV. After assessing interobserver variability, mean score was used to categorise white matter (normal, doubtful or abnormal). Patients with other brain abnormalities were excluded.

Main outcome measures

Hearing and neuromotor evaluation.

Results

Cohen's weighted kappa was 0.79 (95% CI 0.73 to 0.84). White matter was normal in 121 patients, doubtful in 62, abnormal in 28. Median clinical follow-up was 12.0 months (IQR 12.0-27.7 m

SUBMITTER: Vande Walle C 

PROVIDER: S-EPMC10582994 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature