Identification and validation of a necroptosis-related gene prognostic signature for colon adenocarcinoma.

ABSTRACT:

Background

Necroptosis is a novel programmed cell death pathway proposed in 2005, which is mainly activated by the tumor necrosis factor (TNF) family and mediates cellular disassembly via receptor interacting serine/threonine kinase 1 (RIPK1), receptor interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain like pseudokinase (MLKL). We tried to analyze the relationship of necroptosis-related genes (NRGs) expression with colon adenocarcinoma (COAD) and propose potential therapeutic targets through immunological analysis.

Methods

First, we evaluated the expression of NRGs in COAD patients and constructed a prognostic signature. The prognostic signature was validated using The Cancer Genome Atlas (TCGA)-COAD and GSE39582 datasets, respectivel

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10583017 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature