Preclinical efficacy of TZG in myofascial pain syndrome by impairing PI3K-RAC2 signaling-mediated neutrophil extracellular traps.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC10583084 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Preclinical efficacy of TZG in myofascial pain syndrome by impairing PI3K-RAC2 signaling-mediated neutrophil extracellular traps.
Liu Xueting X Mao Xia X Liu Yudong Y Chen Wenjia W Li Weijie W Lin Na N Zhang Yanqiong Y
iScience 20230927 10
Tianhe Zhuifeng Gao (TZG) shows a satisfying therapeutic efficacy in treating arthromyodynia, which shares similar etiology to myofascial pain syndrome (MPS). We herein aim to explore whether TZG could be a potential prescription for MPS therapy. An MPS rat model was successfully established presenting with reduced pain thresholds, abnormal local switch responses, <i>etc.</i>, which was effectively reversed by TZG treatment externally. A transcriptome sequencing based on the active MTrPs samples ...[more]
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