Polygenic risk score predicts risk of primary sclerosing cholangitis in inflammatory bowel disease.

ABSTRACT:

Background

Forty distinct primary sclerosing cholangitis (PSC) genomic loci have been identified through multiancestry meta-analyses. The polygenic risk score (PRS) could serve as a promising tool to discover unique disease behaviour, like PSC, underlying inflammatory bowel disease (IBD).

Aim

To test whether PRS indicates PSC risk in patients with IBD.

Materials and methods

Mayo Clinic and Washington University at St Louis IBD cohorts were used to test our hypothesis. PRS was modelled through the published PSC loci and weighted with their corresponding effect size. Logistic regression was applied to predict the PSC risk.

Results

In total, 63 (5.6%) among 1130 patients with IBD of European ancestry had PSC. Among 381 ulcerative colitis (UC), 12% had PSC; in cont

SUBMITTER: Wang MH 

PROVIDER: S-EPMC10583098 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature