Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial.

ABSTRACT:

Objective

To compare the long term efficacy and safety of rosuvastatin with atorvastatin treatment in adults with coronary artery disease.

Design

Randomised, open label, multicentre trial.

Setting

12 hospitals in South Korea, September 2016 to November 2019.

Participants

4400 adults (age ≥19 years) with coronary artery disease.

Interventions

Participants were assigned to receive either rosuvastatin (n=2204) or atorvastatin (n=2196) using 2×2 factorial randomisation.

Main outcome measures

The primary outcome was a three year composite of all cause death, myocardial infarction, stroke, or any coronary revascularisation. Secondary outcomes were safety endpoints: new onset diabetes mellitus; hospital admissions due to heart failure; deep vein thrombos

SUBMITTER: Lee YJ 

PROVIDER: S-EPMC10583134 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature