Interaction, immune infiltration characteristics and prognostic modeling of efferocytosis-related subtypes in glioblastoma.

ABSTRACT:

Background

Efferocytosis is a biological process in which phagocytes remove apoptotic cells and vesicles from tissues. This process is initiated by the release of inflammatory mediators from apoptotic cells and plays a crucial role in resolving inflammation. The signals associated with efferocytosis have been found to regulate the inflammatory response and the tumor microenvironment (TME), which promotes the immune escape of tumor cells. However, the role of efferocytosis in glioblastoma multiforme (GBM) is not well understood and requires further investigation.

Methods

In this study, we conducted a comprehensive analysis of 22 efferocytosis-related genes (ERGs) by searching for studies related to efferocytosis. Using bulk RNA-Seq and single-cell sequencing data, we analyzed

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10583324 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature