Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) with neuronic development and function is a promising therapeutic agent for treating depressive disorder, according to the neurotrophin hypothesis. However, the delivery of BDNF into the brain is not easy as these large protein molecules cannot efficiently cross the blood-brain barrier (BBB) and easily suffer oxidative damage in vivo. Therefore, the quercetin-based alginate nanogels (quercetin nanogels) loaded with BDNF have been developed, which could efficiently bypass the BBB via the nose-to-brain pathway and protect BDNF from oxidative damage, providing an effective route for the therapy of depressive disorders by intranasal delivery.

Results

Quercetin nanogels exhibited uniform size distribution, excellent biocompatibi

SUBMITTER: Xu D 

PROVIDER: S-EPMC10583373 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature