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Unveiling the role of GAS41 in cancer progression.

ABSTRACT: GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoylation, succinylation, and crotonylation. Functional readouts of these histone modifications often coincide with cancer progression. In addition, GAS41 functions as a novel oncogene, participating in numerous signaling pathways. Here, we summarize the epigenetic functions of GAS41 and its role in the carcinoma progression. Moving forward, elucidating the downstream target oncogenes regulated by GAS41 and the developing small molecule inhibitors based on the distinctive YEATS recognition properties will be pivotal in advancing this research field.

SUBMITTER: Ji K

PROVIDER: S-EPMC10583379 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Unveiling the role of GAS41 in cancer progression.

Ji Kangkang K Li Li L Liu Hui H Shen Yucheng Y Jiang Jian J Zhang Minglei M Teng Hongwei H Yan Xun X Zhang Yanhua Y Cai Yong Y Zhou Hai H

Cancer cell international 20231018 1

GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and development by recognizing essential histone modifications, including histone acetylation, benzoylation, succinylation, and crotonylation. Functional readouts of these histone modifications often coincide with cancer progression. In addition, GAS41 functions as a novel oncogene, participating in n ...[more]

PMID: 37853482

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