Evaluation of different diagnostic methods for spinal tuberculosis infection.

ABSTRACT:

Background and purpose

Tuberculosis (TB) is the most fatal infectious disease worldwide. Approximately 24.6% of tuberculosis cases are extrapulmonary and predominantly affect the spine. It is difficult to diagnose spinal TB (STB). We aimed to evaluate the diagnostic performance of the Mycobacteria Growth Indicator Tube (MGIT)-960 culture, T-SPOT.TB, Xpert Mycobacterium tuberculosis complex (MTB)/resistance to rifampin (RIF), and Metagenomic Next-Generation Sequencing (mNGS) to detect STB.

Methods

We assessed 126 patients presumed to have STB using these four methods. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated using clinical diagnosis as a reference.

Results

Of the patients, 41 were diagnosed with

SUBMITTER: Li Z 

PROVIDER: S-EPMC10583401 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature