KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.

ABSTRACT:

Background

Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these aggressive malignancies have made minimal progress in recent years. Therefore, there is an urgent need to explore the novel therapeutic strategies for this subclass. Histone methylation modulators are critical epigenetic targets for cancer therapies that help maintain the malignancies of cancers harboring TP53 mutations and senescence evasion. Triggering senescence is now considered to benefit multiple cancer therapies. Furthermore, senescence-based "one-two punch" therapy was validated in clinical trials. Therefore, we hypothesized that screening epigenetic modulators might help identify a nove

SUBMITTER: Wang K 

PROVIDER: S-EPMC10583429 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature