Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds.

ABSTRACT: Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrP^C) into an abnormal and misfolded isoform known as PrP^Sc. Most prion diseases and their susceptibility and pathogenesis are mainly modulated by the PRNP gene that codes for PrP. Mutations and polymorphisms in the PRNP gene can alter PrP^C amino acid sequence, leading to a change in transmission efficiency depending on the place where it occurs. Horses are animals that are considered to be highly resistant to prions. Several studies have attempted to identify polymorphisms in the PRNP gene that explain the reason for this high resistance. In this study, we have analysed 207 horses from 20 different breeds, discovering 3 n

SUBMITTER: Sola D 

PROVIDER: S-EPMC10583458 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature