Deciphering intratumoral heterogeneity of hepatocellular carcinoma with microvascular invasion with radiogenomic analysis.

ABSTRACT:

Background and aims

The recurrence and metastasis of hepatocellular carcinoma (HCC) are mainly caused by microvascular invasion (MVI). Our study aimed to uncover the cellular atlas of MVI⁺ HCC and investigate the underlying immune infiltration patterns with radiomics features.

Methods

Three MVI positive HCC and three MVI negative HCC samples were collected for single-cell RNA-seq analysis. 26 MVI positive HCC and 30 MVI negative HCC tissues were underwent bulk RNA-seq analysis. For radiomics analysis, radiomics features score (Radscore) were built using preoperative contrast MRI for MVI prediction and overall survival prediction. We deciphered the metabolism profiles of MVI⁺ HCC using scMetabolism and scFEA. The correlation of Radscore with the level of

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10583459 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature