Integrative proteomic and phosphoproteomic analysis in the female goat hypothalamus to study the onset of puberty.

ABSTRACT:

Background

Puberty marks the end of childhood and achieve sexual maturation and fertility. The role of hypothalamic proteins in regulating puberty onset is unclear. We performed a comprehensive differential proteomics and phosphoproteomics analysis in prepubertal and pubertal goats to determine the roles of hypothalamic proteins and phosphoproteins during the onset of puberty.

Results

We used peptide and posttranslational modifications peptide quantification and statistical analyses, and identified 69 differentially expressed proteins from 5,057 proteins and 576 differentially expressed phosphopeptides from 1574 phosphorylated proteins. Combined proteomic and phosphoproteomics, 759 correlated proteins were identified, of which 5 were differentially expressed only at the prot

SUBMITTER: Ye J 

PROVIDER: S-EPMC10583467 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature