Association of plasma iron with the risk of incident cancer in Chinese adults with hypertension: a nested case-control study.

ABSTRACT:

Background

Iron is an essential element for organismal health but excessive iron is potentially toxic. However, few observational studies link plasma iron (PI) concentrations and cancer risk, and the results are inconsistent.

Objective

This study aimed to explore the associations of PI concentrations with cancer risk in Chinese adults with hypertension.

Methods

We conducted a nested, case-control study, including 223 pairs of incident cancer cases and matched controls from the China Stroke Primary Prevention Trial. The median time between blood sample collection and subsequent cancer event occurrence was 2.13 years. The odds ratio (OR) and 95% confidence interval (CI) for the risk of cancer by PI were estimated from multivariable conditional logistic regression models

SUBMITTER: Zhu H 

PROVIDER: S-EPMC10583576 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature