Diethylcarbamazine elicits Ca²⁺ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles.

ABSTRACT: Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of lymphatic filariasis control. Recent studies have reported that diethylcarbamazine can open transient receptor potential (TRP) channels in the muscles of adult female Brugia malayi, leading to contraction and paralysis. Diethylcarbamazine has synergistic eff

SUBMITTER: Williams PDE 

PROVIDER: S-EPMC10583680 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature