Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis.

ABSTRACT: Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The current regimen that is standard-of-care involves a combination of three different drugs administered for up to one year. There is a critical need for new therapies due to both toxicity and inadequate fungicidal activity of the currently available antifungal drugs. ATI-2307 is a novel aryl amidine that disrupts the mitochondrial membrane potential and inhibits the respiratory chain complexes of fungi-it thus represents a new mechanism for direct antifungal action. Furthermore, ATI-2307 selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells. It has very potent in vitro anticryptococcal activity. In this study, the effic

SUBMITTER: Giamberardino CD 

PROVIDER: S-EPMC10583688 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature