Genome-wide association study of mammary gland tumors in Maltese dogs.

ABSTRACT:

Background

A genome-wide association study (GWAS) is a valuable tool for investigating genetic and phenotypic variation in many diseases.

Objective

The objective of this study was to identify variations in the genomes of Maltese dogs that are associated with the mammary gland tumor (MGT) phenotype and to assess the association between each biological condition and MGT phenotype in Maltese dogs.

Methods

DNA was extracted from 22 tumor samples and 11 whole blood samples from dogs with MGTs. Genome-wide single-nucleotide polymorphism (SNP) genotyping was performed, and the top 20 SNPs associated with various conditions and genetic variations were mapped to their corresponding gene locations.

Results

The genotyping process successfully identified 173,662 loci, with

SUBMITTER: Kim K 

PROVIDER: S-EPMC10583716 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature