Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines.

ABSTRACT: Chagas disease and leishmaniasis are vector-borne infectious diseases affecting both humans and animals. These neglected tropical diseases can be fatal if not treated. Hundreds to thousands of new Chagas disease and leishmaniasis cases are being reported by the WHO every year, and currently available treatments are insufficient. Severe adverse effects, impractical administrations and increased pathogen resistance against current clinical treatments underscore a serious need for the development of new drugs to curb these ailments. In search for such drugs, we investigated a series of nitrofuran-based azine derivatives. Herein, we report the design, synthesis, electrochemistry, and biological activity of these derivatives against promastigotes and amastigotes of Leishmania major, and

SUBMITTER: Saayman M 

PROVIDER: S-EPMC10583827 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature