The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma.

ABSTRACT: The tumor microenvironment is a dynamic network of stromal, cancer, and immune cells that interact and compete for resources. We have previously identified the Vanin1 pathway as a tumor suppressor of sarcoma development via vitamin B5 and coenzyme A regeneration. Using an aggressive sarcoma cell line that lacks Vnn1 expression, we showed that the administration of pantethine, a vitamin B5 precursor, attenuates tumor growth in immunocompetent but not nude mice. Pantethine boosts antitumor immunity, including the polarization of myeloid and dendritic cells towards enhanced IFNγ-driven antigen presentation pathways and improved the development of hypermetabolic effector CD8⁺ T cells endowed with potential antitumor activity. At later stages of treatment, the effect of pantethine wa

SUBMITTER: Miallot R 

PROVIDER: S-EPMC10583838 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature