Dataset Information

Prognostic impact of fluorescent lymphography on gastric cancer.

ABSTRACT:

Background

Fluorescent lymphography-guided lymphadenectomy (FL) for gastric cancer is gaining popularity. However, its impact on prognosis is not known. This study aimed to assess the prognostic impact of FL in gastric cancer patients.

Materials and methods

This study retrospectively analyzed 5678 gastric cancer patients who underwent gastrectomy from 2013 to 2017. The survival was compared between the FLFL group and the conventional lymphadenectomy (non-FL group) using 1:1 propensity score matching after exclusion. Patients in the FL group underwent gastrectomy with systematic lymphadenectomy after endoscopic peritumoral injection of indocyanine green the day before surgery.

Results

After propensity score matching, the FL and non-FL groups each had 1064 patients with similar demographic and clinicopathological characteristics. All matched variables had a standardized mean difference under 0.1. The FL group showed a significantly higher number of retrieved lymph nodes (56.2±20.1) than the non-FL group (46.2±18.2, P <0.001). The FL group also had more stage III patients ( P= 0.044) than the non-FL group. The FL group demonstrated higher overall survival ( P= 0.038) and relapse-free survival ( P= 0.036) in stage III compared with the non-FL group. However, no significant differences in overall and relapse-free survival were observed between the two groups for stages I ( P= 0.420 and P= 0.120, respectively) and II ( P= 0.200 and P= 0.280, respectively).

Conclusion

FL demonstrated a higher survival in stage III gastric cancer patients by the more accurate staging resulting from larger lymph node retrieval. Thus, given its potential to improve prognostication by enhancing staging accuracy, it is recommended as an option to consider the use of FL in clinical practice.

SUBMITTER: Park SH

PROVIDER: S-EPMC10583912 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Prognostic impact of fluorescent lymphography on gastric cancer.

Park Sung Hyun SH Kim Ki-Yoon KY Cho Minah M Kim Yoo Min YM Kim Hyoung-Il HI Hyung Woo Jin WJ

International journal of surgery (London, England) 20231001 10

<h4>Background</h4>Fluorescent lymphography-guided lymphadenectomy (FL) for gastric cancer is gaining popularity. However, its impact on prognosis is not known. This study aimed to assess the prognostic impact of FL in gastric cancer patients.<h4>Materials and methods</h4>This study retrospectively analyzed 5678 gastric cancer patients who underwent gastrectomy from 2013 to 2017. The survival was compared between the FLFL group and the conventional lymphadenectomy (non-FL group) using 1:1 propen ...[more]

PMID: 37352518

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Dataset Information

Prognostic impact of fluorescent lymphography on gastric cancer.

Background

Materials and methods

Results

Conclusion

Publications

Prognostic impact of fluorescent lymphography on gastric cancer.

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