Inference of Capillary Nonperfusion Progression on Widefield OCT Angiography in Diabetic Retinopathy.

ABSTRACT:

Purpose

The purpose of this study was to explore the spatial patterns of the nonperfusion areas (NPAs) on widefield optical coherence tomography angiography (OCTA) images in diabetic retinopathy (DR) and to investigate their associations with NPA progression and DR severity.

Methods

We prospectively enrolled 201 eyes from 158 patients with DR. Widefield images were obtained using a swept-source OCTA device (Xephilio OCT-S1), followed by the creation of 20-mm (1614 pixels) en face images. Nonperfusion squares (NPSs) were defined as 10 × 10-pixel squares without retinal vessels. Eyes with high-dimensional spatial data were mapped onto a two-dimensional space using the uniform manifold approximation and projection algorithm and divided by clustering. The patterns of NPA distrib

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC10584022 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature