Focused analysis of RNFL decay in glaucomatous eyes using circular statistics on high-resolution OCT data.

ABSTRACT: We generated Optical Coherence Tomography (OCT) data of much higher resolution than usual on retinal nerve fiber layer (RNFL) thickness of a given eye. These consist of measurements made at hundreds of angular-points defined on a circular coordinate system. Traditional analysis of OCT RNFL data does not utilize insightful characteristics such as its circularity and granularity for common downstream applications. To address this, we present a new circular statistical framework that defines an Angular Decay function and thereby provides a directionally precise representation of an eye with attention to patterns of focused RNFL loss. By applying to a clinical cohort of Asian Indian eyes, the generated circular data were modeled with a finite mixture of von Mises distributions, which led to an

SUBMITTER: Ali MH 

PROVIDER: S-EPMC10584101 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature