Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation.

ABSTRACT:

Introduction

Cranial irradiation (IR) negatively regulates hippocampal neurogenesis and causes cognitive dysfunctions in cancer survivors, especially in pediatric patients. IR decreases proliferation of neural stem/progenitor cells (NSPC) and consequently diminishes production of new hippocampal neurons. Memantine, an NMDA receptor antagonist, used clinically to improve cognition in patients suffering from Alzheimer's disease and dementia. In animal models, memantine acts as a potent enhancer of hippocampal neurogenesis. Memantine was recently proposed as an intervention to improve cognitive impairments occurring after radiotherapy and is currently under investigation in a number of clinical trials, including pediatric patients. To date, preclinical studies investigating the mechan

SUBMITTER: Zisiadis GA 

PROVIDER: S-EPMC10584145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature