Ten years follow-up of the largest oral Chagas disease outbreak: Cardiological prospective cohort study.

ABSTRACT:

Background

Chagas disease (ChD) is the most important endemy in Latin America. Some patients, develop chronic Chagasic cardiopathy (CCC) years after the acute phase. It is unknown if patients infected by the oral route have higher risk of developing early CCC.

Methods and findings

A prospective cohort study was conducted to assess morbidity and mortality during 10 years observation in 106 people simultaneously infected and treated in the largest known orally transmitted ChD outbreak in 2007. A preschooler died during the acute phase, but thereafter was no mortality associated to ChD. All acute phase findings improved in the first-year post-treatment. Each person was evaluated 8.7 times clinically, 6.4 by electrocardiogram (ECG)/Holter, and 1.7 by echocardiogram. Based on pre

SUBMITTER: Ruiz-Guevara R 

PROVIDER: S-EPMC10584157 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature