Prenatal and postnatal challenges affect the hypothalamic molecular pathways that regulate hormonal levels.

ABSTRACT: This study aimed to improve our understanding of how the hypothalamus mediates the effects of prenatal and postnatal challenges on behavior and sensitivity to stimuli. A pig model of virally initiated maternal immune activation (MIA) was used to investigate potential interactions of the prenatal challenge both with sex and with postnatal nursing withdrawal. The hypothalami of 72 females and males were profiled for the effects of MIA and nursing withdrawal using RNA-sequencing. Significant differential expression (FDR-adjusted p value < 0.05) was detected in the profile of 222 genes. Genes involved in the Gene Ontology biological process of regulation of hormone levels tended to be over-expressed in individuals exposed to both challenges relative to individuals exposed to either one challen

SUBMITTER: Rodriguez-Zas SL 

PROVIDER: S-EPMC10584192 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature