Past human expansions shaped the spatial pattern of Neanderthal ancestry.

ABSTRACT: The worldwide expansion of modern humans (Homo sapiens) started before the extinction of Neanderthals (Homo neanderthalensis). Both species coexisted and interbred, leading to slightly higher introgression in East Asians than in Europeans. This distinct ancestry level has been argued to result from selection, but range expansions of modern humans could provide an alternative explanation. This hypothesis would lead to spatial introgression gradients, increasing with distance from the expansion source. We investigate the presence of Neanderthal introgression gradients after past human expansions by analyzing Eurasian paleogenomes. We show that the out-of-Africa expansion resulted in spatial gradients of Neanderthal ancestry that persisted through time. While keeping the same gr

SUBMITTER: Quilodran CS 

PROVIDER: S-EPMC10584333 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature