Ontology highlight
ABSTRACT:
SUBMITTER: Uceda-Castro R
PROVIDER: S-EPMC10584345 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Uceda-Castro Rebeca R Margarido Andreia S AS Song Ji-Ying JY de Gooijer Mark C MC Messal Hendrik A HA Chambers Cecilia R CR Nobis Max M Çitirikkaya Ceren H CH Hahn Kerstin K Seinstra Danielle D Herrmann David D Timpson Paul P Wesseling Pieter P van Tellingen Olaf O Vennin Claire C van Rheenen Jacco J
Science advances 20231018 42
Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to chemotherapy. However, alternative mechanisms of intrinsic chemoresistance in the chemotherapy-naïve setting may exist but remain poorly understood. Here, we study drug-naïve murine breast cancer brain metastases (BCBMs) to identify how cancer cells growing in a secondary ...[more]