BCRP drives intrinsic chemoresistance in chemotherapy-naive breast cancer brain metastasis.

ABSTRACT: Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to chemotherapy. However, alternative mechanisms of intrinsic chemoresistance in the chemotherapy-naïve setting may exist but remain poorly understood. Here, we study drug-naïve murine breast cancer brain metastases (BCBMs) to identify how cancer cells growing in a secondary site can acquire intrinsic chemoresistance without cytotoxic agent exposure. We demonstrate that drug-naïve murine breast cancer cells that form cancer lesions in the brain undergo vascular mimicry and concomitantly express the adenosine 5'-triphosphate-binding cassette transporter breast cancer res

SUBMITTER: Uceda-Castro R 

PROVIDER: S-EPMC10584345 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature