Astrogliosis, neuritic microstructure, and sex effects: GFAP is an indicator of neuritic orientation in women.

ABSTRACT:

Background

Data from human studies suggest that immune dysregulation is associated with Alzheimer's disease (AD) pathology and cognitive decline and that neurites may be affected early in the disease trajectory. Data from animal studies further indicate that dysfunction in astrocytes and inflammation may have a pivotal role in facilitating dendritic damage, which has been linked with negative cognitive outcomes. To elucidate these relationships further, we have examined the relationship between astrocyte and immune dysregulation, AD-related pathology, and neuritic microstructure in AD-vulnerable regions in late life.

Methods

We evaluated panels of immune, vascular, and AD-related protein markers in blood and conducted in vivo multi-shell neuroimaging using Neurite Orientatio

SUBMITTER: Thaker AA 

PROVIDER: S-EPMC10584366 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature